Pehea ka paclitaxel e hakakā ai i ka maʻi kanesa?

ʻO Paclitaxel kahi diterpenoid i unuhi ʻia mai ka Taxus genus Taxus, a ua ʻike nā kānaka ʻepekema he hana antitumor ikaika kona i nā hoʻokolohua screening.I kēia manawa,paclitaxelua hoʻohana nui ʻia i ka mālama ʻana i ka maʻi kanesa o ka umauma, ka maʻi maʻi ovarian, ka maʻi maʻi ʻaʻai liʻiliʻi liʻiliʻi, ka maʻi ʻaʻai pancreatic, ka maʻi ʻaʻai esophageal, ka maʻi maʻi ʻōpū, ke poʻo a me ka ʻāʻī ʻaʻai, ka sarcoma a me nā maʻi maʻi maʻi ʻē aʻe, a ʻo ia kekahi o nā mea maʻamau. ua hoʻohana i nā lāʻau lapaʻau chemotherapy i ka hana lapaʻau.No laila pehea ka paclitaxel e hakakā ai i ka maʻi kanesa?E nānā kākou ma lalo.

Pehea ka paclitaxel e hakakā ai i ka maʻi kanesa?Ua ʻike maikaʻi ʻia i ka wā o ka hoʻokaʻawale cell maʻamau, ua māhele ʻia ka cell i ʻelua ʻāpana.Ma hope o ka hana hou ʻana o ka chromosome, huki ka spindle filament iā ia mai kona kūlana mua i nā ʻaoʻao ʻelua, a pono ka spindle i ka depolymerization o nā microtubules i ka hana ʻana o ka cytoskeleton, hiki i nā Chromosomes ke hoʻopau i ka mitosis ma ka neʻe ʻana i nā pou ma lalo o ka traction o ka spindle a ka filament spindle, no laila, he mea koʻikoʻi nā microtubules i ka mahele cell.

I ka makahiki 1979, ua ʻike ka lāʻau lapaʻau ʻo Horwitz i kēlāpaclitaxelhiki ke hoʻopaʻa i ka tubulin a hoʻoikaika i ka polymerization o ka tubulin e hana i nā microtubules, no laila ke kāohi nei i ka disaggregation physiological maʻamau o nā microtubules, hiki ʻole iā ia ke hana i nā spindles a me nā filaments spindle, e hana ana i nā cell ʻO ka hiki ʻole ke puʻunaue maʻamau e pale i ka hoʻohou wikiwiki ʻana o nā maʻi kanesa a hoʻoulu i ka apoptosis. o na ma'i ma'i ma'i.No laila, ma waena o nā lāʻau anticancer, ua manaʻo ʻia ʻo paclitaxel he mea hoʻopaneʻe microtubule i ka mitosis.

'Ōlelo Aʻo: Loaʻa ka hopena a me nā noi i wehewehe ʻia ma kēia ʻatikala mai nā puke i paʻi ʻia.

Heluhelu lōʻihi:Ke nānā nei ʻo Yunnan Hande Biotechnology Co., Ltd. i ka hana ʻana o ka paclitaxel no 28 mau makahiki.ʻO ia ka mea hana kūʻokoʻa mua o ka honua i ka paclitaxel lāʻau anticancer i loaʻa i ka mea kanu i ʻae ʻia e ka US FDA, European EDQM, Australian TGA, China CFDA, India, Iapana a me nā keʻena hoʻoponopono aupuni ʻē aʻe.ʻoihana.Inā makemake ʻoe e kūʻaiAPI Paclitaxel,e ʻoluʻolu e kelepona mai iā mākou ma ka pūnaewele.