Lawe iā ʻoe ma ke ala o ka synthesis o paclitaxel

ʻO Paclitaxel kahi metabolite lua maoli i hoʻokaʻawale ʻia a hoʻomaʻemaʻe ʻia mai ka ʻili o ka ʻulaʻula.Ua hōʻoia ʻia i ka maʻi maʻi i loaʻa nā hopena anti-tumor maikaʻi, ʻoi aku ka nui o nā maʻi maʻi ovarian, uterine a me ka umauma, he nui ka nui o ka maʻi kanesa.I kēia manawa,paclitaxel maolia loaʻa ka paclitaxel semi-synthetic ma ka mākeke.ʻO ka ʻatikala aʻe e alakaʻi iā ʻoe ma ke ala o ka synthesis paclitaxel.

Paclitaxellawe ʻia mai ka ʻili a me nā lau o kēia mea kanu, a paʻakikī loa ke kaʻina hana, ʻaʻole hiki ke hoʻoheheʻe ʻia i ka wai a me ka waiʻona, a haʻahaʻa loa ka ʻike, ʻo 100g wale nō, ʻo ia hoʻi ʻelua taels o ka paclitaxel, hiki ke unuhi ʻia mai 30 tons o ka ʻili maloʻo. .ʻOiai ua hoʻopau ʻia kāna synthesis kemika holoʻokoʻa i loko o ka hale hana, pili ia i nā kaʻina he nui, nā kūlana hoʻopaʻapaʻa paʻakikī, ke kumu kūʻai kiʻekiʻe a me nā hua haʻahaʻa.No laila, ʻaʻole hiki ke hana ʻia ma ka hana ʻenehana me ka hoʻohuihui kemika, ʻo ia ke kumu kūʻai nui loa.

Mai ka mea maolipaclitaxelua unuhi ʻia mai ka Pacific yew, he kumu laha ʻole, a he lōʻihi ka pōʻaiapili o ka yew maoli, ma kahi o 13.6 kg o ka ʻili e unuhi i 1 grams o ka paclitaxel, a he 3-12 mau lāʻau yew ma mua o 100 mau makahiki e koi ʻia e mālama i hoʻokahi ovarian. ʻO ka mea maʻi maʻi maʻi, ʻo ka lako wā lōʻihi a me ke kumukūʻai kiʻekiʻe ua alakaʻi i ka hoʻomohala wikiwiki ʻana o ka ʻenehana synthetic o paclitaxel.

I kēia manawa, ʻo ke ʻano nui o ka paclitaxel synthesis ʻo ke ʻano bioengineering, ʻo ia hoʻi ka paclitaxel semisinthesis.Hoʻohana ʻia ke ʻano bioengineering e hana i ka paclitaxel ma kahi ākea nui ma o ka hoʻoulu ʻana a me ka nānā ʻana i nā kānana i hiki ke hana i ka nui o ka paclitaxel, a laila ma ka hoʻomau mau ʻana iā lākou, ka hoʻololi ʻana a me ka hoʻomaikaʻi ʻana i ko lākou ʻano genetic, hiki ke hana ʻia ka paclitaxel i loko o ka moʻomeheu "me ka ʻole. limitation", a ʻaʻole i kaupalena ʻia e ka liʻiliʻi o nā mea maka.Hōʻike nā hopena noiʻi hou loa ua hoʻomaikaʻi maikaʻi ʻia ka hana synthesis e ka 448.52 micrograms o ka paclitaxel no ka lita o ka moʻomeheu moʻomeheu.

ʻO ka synthesis kemika, ʻoiai ua hoʻopau ʻia, ʻaʻole pili i ka ʻoihana ma muli o nā kūlana paʻa i koi ʻia, nā hua haʻahaʻa, a me nā kumukūʻai kiʻekiʻe.ʻO ke ʻano semi-synthetic o ka paclitaxel i kēia manawa ua ʻoi aku ke oʻo a manaʻo ʻia he ala kūpono e hoʻonui ai i ke kumu o ka paclitaxel ma waho aʻe o ka mahiʻai.Hiki i ke ʻano semi-synthetic ke hoʻohana nui i nā kumuwaiwai mea kanu.

'Ōlelo Aʻo: Ua hōʻike ʻia ka pono a me nā noi i uhi ʻia ma kēia pepa mai nā palapala i paʻi ʻia.

Heluhelu lōʻihi:Ke nānā nei ʻo Yunnan Hande Biotechnology Co., Ltd. i ka hana ʻana o ka paclitaxel no 28 mau makahiki.ʻO ia ka mea hana kūʻokoʻa mua o ka honua i ka paclitaxel lāʻau anticancer i loaʻa i ka mea kanu i ʻae ʻia e ka US FDA, European EDQM, Australian TGA, China CFDA, India, Iapana a me nā keʻena hoʻoponopono aupuni ʻē aʻe.ʻoihana.Inā makemake ʻoe e kūʻaiAPI Paclitaxel, e ʻoluʻolu e kelepona mai iā mākou ma ka pūnaewele.