ʻO ka hoʻomohala ʻana o ka paclitaxel he moʻolelo piha i nā wili a me nā pilikia, i hoʻomaka me ka loaʻa ʻana o ka mea hana i loko o ka taxus taxus, hele i loko o nā makahiki he nui o ka noiʻi a me ka hoʻomohala ʻana, a ua lilo i lāʻau anticancer i hoʻohana nui ʻia i loko o ke keʻena.
I ka makahiki 1960, ua hui pū ka National Cancer Institute a me ka US Department of Agriculture i kahi papahana hōʻike hōʻike mea kanu e ʻimi ai i nā lāʻau lapaʻau hou.I ka makahiki 1962, ua hōʻiliʻili ʻo Barclay, he mea kanu lāʻau i ka ʻili a me nā lau mai ka mokuʻāina ʻo Wakinekona a hoʻouna iā lākou i ka NCI e hoʻāʻo ʻia no ka hana anti-cancer.Ma hope o kekahi mau hoʻokolohua, ua hoʻokaʻawale ka hui i alakaʻi ʻia e Kauka Wall a me Kauka Wani i ka paclitaxel i ka makahiki 1966.
ʻO ka loaʻa ʻana o ka paclitaxel ua hoʻohuli nui ʻia a hoʻomaka i kahi kaʻina noiʻi a me ka hoʻomohala nui.I nā makahiki e hiki mai ana, ua hana nā kānaka ʻepekema i nā noiʻi hohonu o ke ʻano kemika o ka paclitaxel a ua hoʻoholo i kona ʻano molecular paʻakikī.I ka makahiki 1971, ua hoʻoholo hou ka hui o Kauka Wani i ke ʻano aniani a me ka spectroscopy NMR opaclitaxel, e kau ana i ke kumu no kona noi lapaau.
Ua hana maikaʻi ʻo Paclitaxel i nā hoʻokolohua lapaʻau a ua lilo ia i lāʻau lapaʻau mua no nā maʻi maʻi maʻi umauma a me nā ovarian a me kekahi mau maʻi maʻi maʻi poʻo, ʻāʻī a me ka pūmāmā.Eia nō naʻe, ua kaupalena ʻia nā kumuwaiwai o ka paclitaxel, e kaupalena ana i kāna noi lapaʻau ākea.I mea e hoʻoponopono ai i kēia pilikia, ua hoʻokō nā kānaka ʻepekema i ka nui o nā haʻawina e ʻimi i ka synthesis o paclitaxel.Ma hope o nā makahiki he nui o ka hoʻoikaika ʻana, ua hoʻomohala ka poʻe i nā ʻano hana like ʻole e synthesize i ka paclitaxel, me ka hui pū ʻana a me ka semi-synthesis.
I ka wā e hiki mai ana, ka noiʻi opaclitaxele hoʻomau i ka hohonu.Me ka holomua mau o ka ʻepekema a me ka ʻenehana, manaʻo ʻia ka poʻe e ʻike i nā mea bioactive hou aʻe e pili ana i ka paclitaxel a hoʻomaopopo hou i kāna ʻano hana.I ka manawa like, me ka hoʻomau mau ʻana o ka ʻenehana synthesis, e ʻoi aku ka maikaʻi o ka synthesis o ka paclitaxel a me ka ʻoluʻolu o ke kaiapuni, i mea e hāʻawi ai i kahi hōʻoia maikaʻi loa no kāna noi lapaʻau ākea.Eia kekahi, e ʻimi pū nā ʻepekema i ka hoʻohana ʻana i ka paclitaxel i hui pū me nā lāʻau anti-cancer ʻē aʻe e hāʻawi i nā koho lapaʻau ʻoi aku ka maikaʻi.
I ka pōkole,paclitaxelhe lāʻau anticancer maoli me ka waiwai lapaʻau koʻikoʻi, a ua piha kāna kaʻina noiʻi a me ka hoʻomohala ʻana i nā luʻi a me nā holomua.I ka wā e hiki mai ana, me ka holomua mau ʻana o ka ʻepekema a me ka ʻenehana a me ka noiʻi hohonu, manaʻo ʻia ʻo paclitaxel e hana nui i ka mālama ʻana i nā ʻano maʻi maʻi ʻē aʻe.
Nānā: Loaʻa nā pono kūpono a me nā noi i hōʻike ʻia ma kēia ʻatikala mai nā palapala i paʻi ʻia.
Ka manawa hoʻouna: Nov-13-2023