Hoʻohana ʻia ʻo Paclitaxel i nā mea lapaʻau

ʻO Paclitaxel, kahi huahana kūlohelohe i lawe ʻia mai ka ʻulaʻula ʻulaʻula, ke kāohi nei i ka mitosis cell tumor ma ka hana ʻana i nā protein microtubule.He ʻelele maʻamau ia o ka papa paclitaxel a ʻo ia ka lāʻau kemika mua loa mai kahi mea kanu maoli i loaʻa ka ʻae ʻana o FDA no ka mālama ʻana i nā ʻano maʻi maʻi like ʻole, e like me ka ovarian, ka umauma, ka māmā, ka sarcoma o Kaposi, nā maʻi maʻi ʻāʻī a me ka pancreatic.I nā makahiki i hala iho nei,paclitaxelua loaʻa pū ka kaulana no ka hoʻohana ʻana i nā mea lapaʻau.E nānā kākou ma ka ʻatikala aʻe.

Hoʻohana opaclitaxelma na mea lapaau

ʻO Paclitaxel, ma o ka polymerization like me ka α (α-tubulin) a me ka β (β-tubulin) o ka microtubulin, ke kumu o ka nui o nā microtubules e polymerize abnormally, ka hopena i ka hoʻololi ʻana i ke kūlana equilibrium skeletal o nā cell a me ka nalowale o ka hana maʻamau, e ho'ōki i ka hoʻomohala ʻana o ka cell i ka pae G0/G1 a me ka pae G1 a me ka GM, a e pale ʻia ka mitosis cell i ka manawa mitotic, i ka hopena e hoʻokō ai i ka pale ʻana i ka mahele ʻana o nā ʻiʻo maʻemaʻe vascular, proliferation ʻO ka hopena ke kāohi i ka māhele a me ka hoʻonui ʻana o ka ʻiʻo maʻemaʻe vascular. a pale i ka restenosis mai ka hiki ʻana mai.

1. Paclitaxellāʻau stent

Drug-eluting stent (DES) he stent e hoʻohana ana i kahi paepae stent metala ʻole e lawe (lawe) i kahi lāʻau anti-endothelial proliferation lāʻau, i hoʻokuʻu ʻia e ka elution kūloko i loko o ka moku e pale pono ai i ka hoʻonui ʻana o ka endothelial i mea e pale ai i ka restenosis i ka stent.ʻO ka hoʻohana maikaʻi ʻana i nā stents drug-eluting i hōʻemi nui i ka nui o ka restenosis a me ka hana hou ʻana, akā ʻaʻole i hōʻemi i ka nui o ka maʻi a me ka make.ʻAʻohe ʻokoʻa koʻikoʻi i ka ulu ʻana o nā hanana hopena lapaʻau ma waena o nā stents drug-eluting, me ka pōmaikaʻi o kekahi mau hope lua.ʻO nā stents lāʻau lapaʻau e komo pū me nā stent ʻaʻole i hana ʻia me ke kila kila a i ʻole cobalt-chromium i uhi ʻia me nā mea lawe lāʻau antiproliferative me nā pale lawe lāʻau polymeric me nā ʻenehana hoʻopuka lāʻau paʻa mau, biodegradable, a me ka polymer-free hoʻopuka lāʻau ʻenehana, a loaʻa nā lāʻau me nā limoxylates a me ka paclitaxel.I kēia manawa, hoʻohana nui ʻia nā stents lāʻau paclitaxel i ka mālama ʻana i nā maʻi like ʻole o ka coronary, intracranial, carotid, renal and femoral arteries.

2. Paclitaxel nā baluna i uhi ʻia i ka lāʻau

Ua hōʻike ʻia ʻo Baluna i uhi ʻia i ka lāʻau (DCB), ma ke ʻano he ʻenehana interventional hou a makua, i kekahi mau hoʻokolohua lapaʻau no ka maikaʻi a me ka palekana i ka ISR, intracoronary stenosis lesions, liʻiliʻi moku liʻiliʻi, bifurcation lesions, etc.

'Ōlelo Aʻo: Loaʻa ka pono a me nā noi i wehewehe ʻia ma kēia ʻatikala mai nā palapala i paʻi ʻia.

Heluhelu lōʻihi:Ke nānā nei ʻo Yunnan Hande Biotechnology Co., Ltd. i ka hana ʻana o ka paclitaxel no 28 mau makahiki.ʻO ia ka mea hana kūʻokoʻa mua o ka honua i ka paclitaxel lāʻau anticancer i loaʻa i ka mea kanu i ʻae ʻia e ka US FDA, European EDQM, Australian TGA, China CFDA, India, Iapana a me nā keʻena hoʻoponopono aupuni ʻē aʻe.ʻoihana.Inā makemake ʻoe e kūʻaiAPI Paclitaxel, e ʻoluʻolu e kelepona mai iā mākou ma ka pūnaewele.