ʻO Paclitaxel (Paclitaxel) kahi lāʻau anticancer kūlohelohe i unuhi ʻia mai ka mea kanu yew, nona ka ʻano kemika kūʻokoʻa a me nā hopena pharmacological.Mai ka loaʻa ʻana o ka paclitaxel i ka makahiki 1971, ua loaʻa i kāna noi lapaʻau nā hopena kupaianaha.Ma keia pepa, ka hana kemika a me ka pharmacological hana opaclitaxele kūkākūkā ʻia.
ʻO ke kinona o ka paclitaxel
He paʻakikī ka hoʻolālā kemika o ka paclitaxel, aia kekahi mau ʻāpana apo, me kahi ʻano diterpenoid kumu, kahi ʻāpana nui o ka hopena anti-cancer o paclitaxel.Loaʻa i nā molekala Paclitaxel kekahi mau pūʻulu hydroxyl a me ketone, a ʻo ka wahi a me ka helu o kēia mau pūʻulu e hoʻoholo i kāna hana lāʻau lapaʻau kūikawā.
Nā hopena pharmacological o ka paclitaxel
1. Microtubule stabilization: Hiki i ka Paclitaxel ke hoʻoikaika i ka polymerization o nā microtubules a hoʻopaʻa i nā microtubules polymerized, ʻo ia ke kumu nui o kāna hopena anticancer.He kuleana koʻikoʻi nā Microtubules i ka mahele pūlima, a ke kāohi nei ka paclitaxel i ka ulu ʻana o ka maʻi ma o ka hoʻopaʻa ʻana i nā microtubules a me ka pale ʻana i ka māhele cell.
2, hoʻoulu i ka hopu ʻana i ka pōʻaiapili kelepona: hiki i ka paclitaxel ke hoʻoulu i ka hopu ʻana i ka pōʻaiapili cell, i hiki ʻole i nā cell ke hoʻomau i ka māhele a hoʻonui.ʻO kēia kekahi hana koʻikoʻi o kāna hopena anticancer.
3, hoʻoulu i ka apoptosis: hiki i ka paclitaxel ke hoʻoulu i ka hōʻike ʻana o kekahi mau mea hoʻolaha pro-apoptosis, e hoʻolalelale i ke kaʻina hana apoptosis o nā maʻi maʻi maʻi.
4, hoʻoponopono i nā mea hoʻoponopono anti-apoptotic: hiki i ka paclitaxel ke hoʻoponopono i ka hana o nā mea hoʻoponopono anti-apoptotic e kaulike i ke kaʻina o ka apoptosis a me ka hoʻonui.
Ka hopena
He ʻano lāʻau anticancer maoli ʻo Paclitaxel me kahi ʻano kemika kūʻokoʻa a me ka hana pharmacological.Hiki iā ia ke pale pono i ka ulu ʻana o ka maʻi maʻi ma o ka hoʻolaha ʻana i ka polymerization microtubule, hoʻopaʻa i nā microtubules polymerized, hoʻoulu i ka hopu ʻana o ka cell cycle a hoʻoulu i ka apoptosis cell.Eia nō naʻe, ʻo ka ʻona a me nā hopena ʻaoʻao o ka paclitaxel kekahi mea hopohopo i nā noi lapaʻau.ʻO ka noiʻi hou a me ka hoʻomaopopo ʻana i nā hopena pharmacological o ka paclitaxel e kōkua i ka hoʻohana ʻana i ka lāʻau lapaʻau, hoʻomaikaʻi i ka hopena therapeutic, a hōʻemi i nā hopena ʻaoʻao.
Manao e hiki mai ana
ʻOiai ua loaʻa i ka hoʻohana lāʻau lapaʻau o paclitaxel nā hopena kupaianaha, aia nō ka pilikia o kāna mau kumuwaiwai liʻiliʻi a me ka lako paʻa.No laila, ke hana nei nā kānaka ʻepekema i ka biology synthetic a me ka chemistry medicinal e ʻimi i nā mea ʻē aʻe i ka paclitaxel e hoʻoponopono i nā pilikia lako a hoʻemi i nā kumukūʻai hana.Eia kekahi, noiʻi i nā hopena pharmacological opaclitaxelE kōkua nō hoʻi ia e ʻike i nā hoʻolālā lapaʻau ʻoi aku ka maikaʻi e hoʻoponopono i nā ʻano maʻi maʻi like ʻole.
I nā haʻawina preclinical a me nā hoʻokolohua lapaʻau, ʻo ka hui pū ʻana o ka paclitaxel a me nā lāʻau anticancer ʻē aʻe i hōʻike i nā manaʻo hoʻohiki.Ma ka hoʻohui ʻana i ka paclitaxel me nā lāʻau lapaʻau ʻē aʻe, hiki ke hoʻonui ʻia ka maikaʻi o ka mālama ʻana a hoʻemi ʻia ka puka ʻana o ke kū'ē.I ka wā e hiki mai ana, me ka hoʻolaha ʻana o ka lāʻau lapaʻau pololei a me nā manaʻo lapaʻau pilikino, ʻoi aku ka hohonu o ka noiʻi a me ka hoʻomaopopo ʻana i nā hopena pharmacological o ka paclitaxel, a e hāʻawi ʻia nā papahana lapaʻau kūpono a maikaʻi hoʻi no nā maʻi maʻi maʻi.
Ma keʻano laulā, ʻo ka paclitaxel kahi lāʻau anticancer kūlohelohe me kahi ʻano kemika kūʻokoʻa a me nā hopena pharmacological.Me ka holomua mau o ka ʻepekema a me ka ʻenehana a me ka noiʻi hohonu, ke kakali nei mākoupaclitaxelʻoi aku ka nui o ka mālama ʻana i nā maʻi maʻi like ʻole i ka wā e hiki mai ana, e lawe ana i nā hopena lapaʻau maikaʻi aʻe a me ka maikaʻi o ke ola i nā maʻi.
Nānā: Loaʻa nā pono kūpono a me nā noi i hōʻike ʻia ma kēia ʻatikala mai nā palapala i paʻi ʻia.
Ka manawa hoʻouna: Nov-15-2023