ʻO Paclitaxel kahi lāʻau anticancer koʻikoʻi, a ʻo kona ʻano kūʻokoʻa a me kāna hana olaola ua huki nui ʻia e ka poʻe ʻepekema. E like me kāna kumu a me ke ʻano hoʻomākaukau, hiki ke hoʻokaʻawale ʻia ka paclitaxel i ka paclitaxel maoli a me ka paclitaxel semi-synthetic. E kūkākūkā kēia ʻatikala i nā ʻokoʻa a me nā pono. o laua.
Puna a me ke ʻano hoʻomākaukau
Paclitaxel maoli: Lawe ʻia ka paclitaxel kūlohelohe mai ka lāʻau yew Pākīpika (Taxus brevifolia).
Paclitaxel semi-synthetic: Hoʻohui ʻia ka paclitaxel semi-synthetic e ka synthesis kemika mai nā ʻauhau i unuhi ʻia mai ka ʻili o ka taxus chinensis. Hiki ke hoʻohana ʻia kēia ʻano hana no ka hana ʻana i ka paclitaxel ma ke ʻano nui e hoʻokō i nā pono lapaʻau.
ʻO ke kinona
ʻOiai ʻokoʻa iki ka paclitaxel maoli a me ka paclitaxel semi-synthetic i ka hoʻolālā kemika, ua like ko lākou ʻano kumu, a he mau alkaloids diterpenoid ʻelua.
Ka hana olaola a me ka pono
Paclitaxel maoli: Ma ka hana lapaʻau, ua hōʻike ʻia ka paclitaxel kūlohelohe i ka hopena therapeutic koʻikoʻi i nā ʻano maʻi maʻi like ʻole, me ka maʻi kanesa o ka umauma, ka maʻi ʻaʻai ovarian, kekahi mau maʻi maʻi poʻo a me ka ʻāʻī, a me ka maʻi maʻi ʻāʻī. o ka tubulin a me ka luku ʻana i ka pūnaewele microtubule cell, no laila ke keʻakeʻa nei i ka hoʻonui ʻana o ka cell a hoʻoulu i ka apoptosis o nā maʻi maʻi.
Paclitaxel Semi-synthetic: He like ka paclitaxel semi-synthetic i ka pono me ka paclitaxel maoli a loaʻa pū kekahi hana anticancer.
Nā hopena ʻino
Paclitaxel maoli: He haʻahaʻa loa ka ʻona o ka paclitaxel maoli, akā hiki ke hoʻoulu i kekahi mau hopena maikaʻi ʻole, e like me ka hopena maʻi, ka hoʻopau ʻana i ka iwi iwi a me ka ʻona o ka naʻau.
Paclitaxel Semi-synthetic: ʻO nā hopena ʻaoʻao o ka paclitaxel semi-synthetic ua like ia me nā paclitaxel maoli.
Nā Manaʻo hoʻomohala e hiki mai ana
Me ka holomua mau o ka ʻepekema a me ka ʻenehana, ke hoʻonui nei ka noiʻi ʻana i ka paclitaxel. hiki i ka hoʻomohala ʻana i nā ʻenehana hou e like me ka genetic engineering a me ka cell therapy, nā hoʻolālā lapaʻau pilikino no ka paclitaxel e hiki nō hoʻi, no laila e hāʻawi ana i nā maʻi maʻi maʻi i nā koho lapaʻau kūpono a maikaʻi.
Ka hopena
ʻeluapaclitaxel maoliapaclitaxel semi-syntheticLoaʻa i ka hana anticancer koʻikoʻi i ka hoʻomaʻamaʻa lapaʻau. ʻOiai he ʻokoʻa ko lākou kumu a me nā ʻano hoʻomākaukau, ua like like lākou i ka hana kemika, ka hana olaola a me ka pharmacodynamics. Ma nā haʻawina e hiki mai ana, e hoʻomau ka poʻe ʻepekema i ka ʻimi ʻana i nā ʻano hana olaola o ka hana a me nā wahi noi o ka paclitaxel e lawe mai i ka manaʻolana lapaʻau i nā maʻi maʻi maʻi.
'Ōlelo Aʻo: Loaʻa nā pōmaikaʻi a me nā noi i hōʻike ʻia ma kēia ʻatikala mai nā palapala i paʻi ʻia.
Ka manawa hoʻouna: Nov-29-2023