ʻO Taxus chinensis(Yew), he ʻano lāʻau kahiko i waiho ʻia ma hope o ka Quaternary glacier, ua helu ʻia ʻo ia nā mea kanu kakaʻikahi a me ka pōʻino o ka honua a ʻo ka ʻumi o nā ʻano lāʻau weliweli loa o ka honua. "mea kanu panda nunui".
No laila,
Ma ke ʻano he "moʻalipo ola o nā mea kanu", he aha nā hopena a me nā hoʻohana ʻana o ka yew extract?
ʻO Yew, he mea kanu Taxus o Taxaceae. Aia he 11 mau ʻano yew ma ka honua, i puʻunaue ʻia ma nā ʻāina ʻoluʻolu o ka ʻaoʻao ʻākau. ,South yew a me Tibet yew, ka mea i puunaueia ma Northeast, South China a me ke komohana hema o Kina. Paclitaxel extracted from the bark and leaves of yew has outstanding curative effect on a variety of advanced cancers and is known as "the last line of defense for the lapaʻau ʻana i ka maʻi kanesa”.
ʻO ka mōʻaukala hoʻomohala o paclitaxel:
I ka makahiki 1963, ua hoʻokaʻawale mua nā mea hoʻomaʻamaʻa ʻAmelika ʻo MCWani lāua ʻo monre E.wall i ka ʻili o ka paclitaxel mai ka ʻili a me ka lāʻau o ka Pacific yew, e ulu ana ma nā ululāʻau o ke komohana o ʻAmelika Hui Pū ʻIa. ʻO ka extract crude o ka paclitaxel he hana kiʻekiʻe ma luna o nā pūnaewele ʻiole i loko o ka vitro, a hoʻomaka e hoʻokaʻawale i kēia mea hana. ,he polopeka kemika ma ke Kulanui o Duke e hoʻoholo i ke ʻano kemika o ka mea hoʻoikaika-he pūhui diterpene tetracyclic, a kapa ʻia ʻo ia ʻo taxol.
He aha ka paclitaxel?
ʻO Paclitaxel kahi monomer diterpenoid i unuhi ʻia mai ka ʻili o ka Natural Plant Taxus. ʻAʻole e pane me nā dimer tubulin unpolymerized. Ma hope o ka hoʻopili ʻana i ka paclitaxel, e hōʻiliʻili nā cell i kahi helu nui o nā microtubules i loko o nā cell. ʻO ka hōʻiliʻili ʻana o kēia mau microtubules e hoʻopilikia i nā hana like ʻole o nā cell, ʻoi aku ka hoʻopau ʻana i ka māhele cell i ka mitotic stage a poloka i ka mahele cell maʻamau.
Ka hoʻohana ʻana i ka paclitaxel:
1. Ka maʻi maʻi maʻi
'O Paclitaxel ka lā'au lapa'au mua no ka ma'i 'a'ai ovarian a me ka ma'i 'a'ai umauma.
Hoʻohana nui ʻia ʻo Paclitaxel i ka maʻi maʻi ovarian a me ka maʻi maʻi umauma ma o ka lua-a me ke kolu o ka hoʻopaʻa ʻana.
2.Aiʻiʻo
ʻO Paclitaxel ka koho mua o nā lāʻau anti-tumor i nā halemai ma ka honua holoʻokoʻa. Hiki iā ia ke hoʻoikaika i ka hui ʻana o nā microtubules ma ka hoʻolaha ʻana i ka polymerization o nā subunits spindle tubulin. He lāʻau anti-microtubule antitumor lāʻau.
3. Ka mālama ʻana i ka maʻi rumatika
Ua hōʻike ʻia nā haʻawina ua ʻae ʻia ka taxol e FDA no ka rheumatoid arthritis, a ʻo ka paclitaxel gel kahi hoʻomākaukau topical no ka paclitaxel i ka rheumatoid arthritis.
Ka manawa hoʻouna: Apr-21-2022