ʻO ka paclitaxel kūlohelohe: kahi lāʻau anticancer maikaʻi loa a haʻahaʻa loa

ʻO Paclitaxel, kahi lāʻau anticancer kūlohelohe me ke ʻano C47H51NO14, ua hoʻohana nui ʻia i ka mālama ʻana i ka maʻi kanesa o ka umauma, ka maʻi ʻaʻai ovarian a me kekahi mau maʻi maʻi maʻi poʻo, ʻāʻī a me ka māmā.Me he alkaloid diterpenoid me ka hana anticancer,paclitaxelUa makemake nui ʻia e nā botanists, chemists, pharmacologists a me molecular biologists ma muli o kāna moʻolelo a me ka paʻakikī o ka hana kemika, ka nui a koʻikoʻi o ka hana olaola, ka hana hou a me ka ʻokoʻa o ka hana, a me ka liʻiliʻi o nā kumuwaiwai kūlohelohe, e lilo ia i hōkū a me ka nānā ʻana o ka anticancer ma ka hapa lua o ke kenekulia 20.

ʻO ka hana o ka paclitaxel

Kāohi ʻo Paclitaxel i ka hoʻonui ʻana o nā maʻi maʻi maʻi ma o ka hoʻoulu ʻana i ka hopu ʻana o ka pōʻai cell a hoʻoulu i ka pōʻino mitotic.Hāʻawi kona ʻano hou a paʻakikī hoʻi i ke ʻano hana biological o ka hana.Paclitaxelhiki ke pale i ka hoʻonui ʻana o ka cell ma ke kāohi ʻana i ka polymerization o ka tubulin a me ka luku ʻana i ka pūnaewele microtubule cell.Eia hou, hiki i ka paclitaxel ke hoʻoulu i ka hōʻike o nā mea hoʻolaha pro-apoptotic a hoʻoponopono i ka hana o nā mediators anti-apoptotic, a laila e hoʻoulu ai i ka apoptosis o nā pūnaeho maʻi maʻi.

Ka hana anti-cancer o paclitaxel

Ua ʻike nui ʻia ʻo Paclitaxel ma muli o kāna hana kiʻekiʻe a me ka haʻahaʻa haʻahaʻa o ka hana anticancer.I loko o ka hoʻomaʻamaʻa lapaʻau, ua hōʻike ʻia ka paclitaxel i nā hopena therapeutic koʻikoʻi i nā ʻano maʻi maʻi like ʻole, e like me ka maʻi maʻi umauma, ka maʻi maʻi ovarian, kekahi mau maʻi maʻi poʻo a me ka ʻāʻī, a me ka maʻi kanesa.Ma o kāna hana olaola kū hoʻokahi, hiki i ka paclitaxel ke pale pono i ka hoʻonui ʻana o nā maʻi maʻi maʻi a hoʻoulu i ka apoptosis o nā maʻi kanesa.Eia kekahi, pili pū ka hana anti-cancer o paclitaxel i kona hiki ke hoʻoponopono i ka pane ʻana o ka maʻi maʻi o nā pūnaewele tumo.

Ka liʻiliʻi o ka paclitaxel

ʻOiai he hana anticancer koʻikoʻi ka paclitaxel, ua kaupalena ka liʻiliʻi kumu waiwai i kāna hoʻohana lapaʻau ākea.Lawe ʻia ʻo Paclitaxel mai nā lāʻau yew Pākīpika, a ma muli o ka liʻiliʻi o nā kumuwaiwai kūlohelohe, mamao loa ka hana ʻana o ka paclitaxel mai ka hoʻokō ʻana i nā pono lapaʻau.No laila, ʻo ka ʻimi ʻana i nā kumu hou o ka paclitaxel, e like me ka hana ʻana o ka paclitaxel ma o biosynthesis a i ʻole synthesis chemical, ʻo ia ke kumu o ka noiʻi o kēia manawa.

hopena

Ma ke ʻano he lāʻau anticancer maoli,paclitaxelLoaʻa iā ia nā hiʻohiʻona o ka hana kiʻekiʻe, haʻahaʻa haʻahaʻa a me ka laulā ākea, a me kāna ʻano hana kūlohelohe kūikawā o ka hana a me ka hana anticancer nui e lilo ia i lāʻau lapaʻau koʻikoʻi i ka lāʻau lapaʻau.Eia nō naʻe, ma muli o ka liʻiliʻi o kāna mau kumuwaiwai, ua kaupalena ʻia kāna noi ākea i ka hana lapaʻau.No laila, pono ka noiʻi e hiki mai ana i ka ʻimi ʻana i nā kumu hou o ka paclitaxel e hoʻokō i nā pono lapaʻau a hāʻawi i nā koho lapaʻau hou aku no nā maʻi maʻi maʻi.

Nānā: Loaʻa nā pono kūpono a me nā noi i hōʻike ʻia ma kēia ʻatikala mai nā palapala i paʻi ʻia.