ʻO ka Paclitaxel kahi hui kūlohelohe i unuhi ʻia mai ka lāʻau yew, a he hana anti-tumor koʻikoʻi. e ʻimi hohonu i nā hopena lapaʻau opaclitaxelma nā ʻano maʻi kanesa like ʻole.
ʻO ke ʻano a me nā waiwai o ka paclitaxel
ʻO Paclitaxel kahi pūhui diterpenoid tetracyclic paʻakikī me ka hoʻolālā ʻekolu-dimensional, kahi e hāʻawi ai i ke kumu no kāna hana anti-tumor. ʻO kona molecular formula C47H51NO14, molecular weight 807.9, a he māmā melemele crystalline pauka i ka lumi wela.
Mekani-cancer opaclitaxel
ʻO ka hana anti-cancer o ka paclitaxel e pili nui ana i kona kaohi ʻana i ka depolymerization tubulin a me kona hopena i ka māhele cell a me ka hoʻonui. i ka make cell. Eia kekahi, hiki i ka paclitaxel ke hoʻoulu i ka apoptosis cell a keʻakeʻa i ka angiogenesis tumor.
ʻO ka hopena therapeutic o ka paclitaxel ma nā ʻano maʻi maʻi like ʻole
1. Ka maʻi 'aʻai umauma: Ua ʻike nui ʻia ka hopena lapaʻau o ka paclitaxel ma ka maʻi kanesa o ka umauma. Ma kahi noiʻi ʻana o 45 mau maʻi maʻi maʻi umauma, ʻo ka paclitaxel i hui pū ʻia me ka chemotherapy ka hopena i ka emi ʻana o ka maʻi maʻi i 41% o nā maʻi a me ke ʻano o ke ola ʻana ma mua o 20 mau mahina.
2.Non-small cell lung cancer:No ka non-liʻiliʻi cell lung cancer, paclitaxel i hui pū ʻia me ka platinum-based chemotherapy drugs hiki ke hoʻomaikaʻi nui i ke ola o nā maʻi. ʻO ka chemotherapy i hopena i ke ola ma waena o 12 mahina.
3.Ovarian cancer: I ka mālama ʻana i nā maʻi maʻi maʻi ovarian 70, hui pū ʻia ʻo paclitaxel me nā lāʻau lapaʻau lapaʻau platinum i hoʻemi ʻia i nā maʻi maʻi ma 76% o nā mea maʻi, a hiki i ka helu ola ʻelua makahiki i 38%.
4. Esophageal maʻi 'aʻai: I ka mālama 'ana i 40 maʻi me ka esophageal maʻi 'aʻai, paclitaxel hui me ka radiotherapy hoemi maʻi koko ma 85% o na maʻi, a me ka makahiki hoʻokahi ola ola hiki i 70%.
5.Gastric cancer:I ka mālama ʻana i ka maʻi maʻi ʻōpū, hiki i ka paclitaxel i hui pū ʻia me ka fluorouracil ke hoʻomaikaʻi nui i ke ola o nā maʻi.paclitaxelhui pū ʻia me ka chemotherapy i hopena i ke ola ma waena o 15 mau mahina.
6.Colorectal maʻi 'aʻai: Ma ka mālama 'ana o 30 colorectal maʻi 'aʻai maʻi 'aʻai, paclitaxel hui me oxaliplatin hoemi maʻi koko i loko o 80% o na maʻi, a me ka elua makahiki ola maʻi i hiki i 40%.
7. Ka ma'i 'a'ai: 'Oiai ua kaupalena 'ia ka hopena o ka paclitaxel monotherapy i ka ma'i 'a'ai, 'o ka hui 'ana o nā lā'au lapa'au chemotherapy e like me cisplatin a me 5-fluorouracil hiki ke ho'omaika'i nui i ke ola o ka po'e ma'i. me ka chemotherapy i hopena i ke ola ma waena o 9 mahina.
8. Ka maʻi 'aʻai maʻi: I ka mālama ʻana i ka maʻi maʻi ʻaʻai, ʻo ka paclitaxel i hui pū ʻia me nā lāʻau immunomodulatory e like me interferon-alpha hiki ke hoʻomaikaʻi nui i ke ola o nā maʻi. 24 mahina.
9. Leukemia: I ka mālama ʻana i ka maʻi leukemia myeloid acute, hiki i ka paclitaxel i hui pū ʻia me nā lāʻau lapaʻau chemotherapy e like me ka cytarabine ke hoʻokō i nā mea maʻi i kahi kiʻekiʻe o ke kala kala piha. ma 80% o nā maʻi.
10,lymphoma: I ka mālama ʻana i ka lymphoma non-Hodgkin, hiki i ka paclitaxel i hui pū ʻia me nā lāʻau lapaʻau chemotherapy e like me cyclophosphamide ke hiki i nā mea maʻi ke hoʻokō i kahi kiʻekiʻe o ka pane piha piha. i ka pane piha i 85% o nā maʻi.
Ka hopena
I ka hōʻuluʻulu manaʻo, ua hōʻike ʻo paclitaxel i kekahi ʻano kūpono i ka mālama ʻana i nā ʻano like ʻole o ka maʻi kanesa. paʻakikī a me nā ʻokoʻa o kēlā me kēia kanaka o ka maʻi kanesa, pono e hoʻopilikino ʻia nā hoʻolālā lapaʻau no kēlā me kēia maʻi.
'Ōlelo Aʻo: Loaʻa nā pōmaikaʻi a me nā noi i hōʻike ʻia ma kēia ʻatikala mai nā palapala i paʻi ʻia.
Ka manawa hoʻouna: Nov-17-2023