Ua noʻonoʻo ʻia nā lāʻau lapaʻau ʻo Paclitaxel ka lāʻau lapaʻau mua no ka maʻi kanesa o ka umauma, a ua hoʻohana nui ʻia no ka maʻi maʻi ovarian, ka maʻi ʻāʻī, ka maʻi maʻi poʻo a me ka ʻāʻī, ka maʻi maʻi esophageal, ka maʻi ʻōpū a me ka sarcoma ʻiʻo palupalu.I kēia mau makahiki i hala iho nei, ma o ka ʻimi hoʻomau ʻana i nā lāʻau paclitaxel a me ka hoʻomaikaʻi mau ʻana o ke kaʻina hana, ʻo kēia mau lāʻau lapaʻau i kēia manawa ka nui o ka paclitaxel injection, docetaxel (docetaxel), liposomal paclitaxel a me albumin-bound paclitaxel.No laila he aha nā ʻokoʻa ma waena o kēia mau lāʻau paclitaxel, e aʻo hou e pili ana iā lākou ma lalo nei.
I. Nā ʻokoʻa i nā hana kumu
1. Paclitaxel injection: Ua hōʻike ʻia no ka lālani mua a me ka mālama ʻana i ka maʻi maʻi ovarian progressive, adjuvant treatment of lymph node-positive breast cancer after a regimen standard of adriamycin-containing combination chemotherapy, breast cancer in metastatic breast cancer that ʻAʻole i hāʻule ka chemotherapy hui a i ʻole ka hoʻihoʻi ʻana i loko o 6 mau mahina o ka adjuvant chemotherapy, ka lāʻau lapaʻau mua o ka maʻi maʻi ʻaʻai liʻiliʻi liʻiliʻi ʻole, a me ka lāʻau lua o ka maʻi carcinosarcoma pili i ka maʻi AIDS.
2. Docetaxel: No ka mālama ʻana i ka maʻi maʻi maʻi maʻi kiʻekiʻe a i ʻole metastatic i hāʻule ʻole ma mua o ka chemotherapy;no ka mālama ʻana i ka maʻi maʻi ʻaʻai maʻi maʻi ʻaʻole liʻiliʻi liʻiliʻi i hiki ʻole ke hoʻohana ʻia me ka cisplatin-based chemotherapy.He mea maikaʻi hoʻi ia no ka maʻi maʻi ʻōpū a me ka maʻi prostate.
3. Liposomal paclitaxel: Hiki ke hoʻohana ʻia e like me ka chemotherapy laina mua no ka maʻi maʻi ovarian a me ka chemotherapy laina mua no ka mālama ʻana i ka maʻi kanesa metastatic ovarian, a hiki ke hoʻohana pū ʻia me ka cisplatin.Hiki ke hoʻohana ʻia no ka mālama ʻana i nā maʻi maʻi maʻi umauma i mālama ʻia me ka chemotherapy maʻamau i loaʻa ka adriamycin a i ʻole no ka mālama ʻana i nā maʻi me ka hoʻi hou ʻana.Hiki ke hoʻohana pū ʻia me ka cisplatin ma ke ʻano he chemotherapy laina mua no nā poʻe maʻi me ka maʻi maʻi ʻaʻai liʻiliʻi liʻiliʻi ʻaʻole hiki ke mālama ʻia me ke ʻoki a i ʻole radiotherapy.
4. Paclitaxel paʻa i ka Albumin: hōʻike ʻia no ka mālama ʻana i ka maʻi maʻi umauma metastatic i hāʻule i ka chemotherapy hui a i ʻole no ka maʻi maʻi umauma i hoʻi hou i loko o 6 mau mahina ma hope o ka adjuvant chemotherapy.Inā ʻaʻole he contraindication maʻi, pono e hoʻokomo i ka lāʻau lapaʻau mua i kahi mea anthracycline anticancer agent.
II.Nāʻokoʻa o ka palekana lāʻau
1. Paclitaxel: hiki ke hoʻonāwaliwali i ka wai.ʻO ka maʻamau, e hoʻohui ka inikini i nā surfactants polyoxyethylene-substituted castor oil a me ethanol e hoʻomaikaʻi i ka solubility o ka paclitaxel i loko o ka wai, akā hoʻokuʻu ʻia ka histamine i ka wā i hoʻohaʻahaʻa ʻia ai ka ʻaila castor polyoxyethylene-substituted in vivo, hiki ke alakaʻi i nā hopena maʻi koʻikoʻi a hiki ke hōʻeha. ʻO ka neurotoxicity peripheral o paclitaxel, a hiki ke hoʻopili i ka hoʻolaha ʻana o nā molekala lāʻau i nā ʻiʻo a pili i ka hopena anti-tumor.
2. Docetaxel: he haʻahaʻa ka hoʻoheheʻe wai, a pono e hoʻoheheʻe ʻia ma ka hoʻohui ʻana i ka polysorbate 80 a me ka ethanol anhydrous, ʻo ia mau mea ʻelua e hiki ke hoʻonui i ka hopena o nā hopena ʻino a hiki ke hoʻoulu i ka maʻi a me ka hemolytic.
3. Liposomal paclitaxel: ua hoʻopili ʻia ka lāʻau lapaʻau i loko o ka lipid-like bilayers e hana i nā vesicle liʻiliʻi, a ua hoʻopili ʻia ka lāʻau lapaʻau i loko o nā ʻāpana liposomal me ka ʻole o ka polyoxyethylene-substituted castor oil a me anhydrous ethanol, kahi e hoʻoulu ai i ka maʻi.Eia nō naʻe, ua hōʻike ʻia nā haʻawina e hiki nō i ka lāʻau paclitaxel ponoʻī ke hoʻoulu i nā hopena hypersensitivity, akā ma kahi haʻahaʻa haʻahaʻa e hoʻohālikelike ʻia me ka paclitaxel injection.I kēia manawa, koi mau nā liposomes paclitaxel i ka mālama mua ʻana i ka allergy ma mua o ka hoʻohana ʻana.
4. Paclitaxel paʻa i ka Albumin: He mea hou paclitaxel albumin lyophilized agent e hoʻohana ana i ka albumin kanaka ma ke ʻano he mea lawe lāʻau a me ka stabilizer, ʻaʻole i loaʻa ka co-solvent polyoxyethylene-substituted castor oil a he haʻahaʻa haʻahaʻa paclitaxel maʻiʻo me nā liposomes paclitaxel, a ʻaʻole i loaʻa. pono e hoʻomaʻamaʻa mua ʻia ma mua o ka mālama ʻana.
'Ōlelo Aʻo: ʻO ka pono a me nā noi i uhi ʻia ma kēia hōʻikeʻike ua lawe ʻia mai nā palapala i paʻi ʻia.
ʻO Yunnan Hande Biotechnology Co., Ltd ua loea i ka hana ʻana oAPI paclitaxelno nā makahiki ʻoi aku ma mua o 20, a ʻo ia kekahi o nā mea hana kūʻokoʻa o ka honua i ka paclitaxel API, kahi lāʻau anti-cancer i loaʻa i nā mea kanu, i ʻae ʻia e ka US FDA, European EDQM, Australian TGA, Chinese CFDA, India, Iapana a me nā keʻena hoʻoponopono aupuni ʻē aʻe. .Hiki i ka Hande ke hāʻawi i ka mea kiʻekiʻe wale nōpaclitaxel maka, akā, ʻo nā lawelawe hoʻomaikaʻi ʻenehana e pili ana i ka hana paclitaxel.No ka ʻike hou aku, e ʻoluʻolu e kelepona mai iā mākou ma 18187887160.
Ka manawa hoʻouna: Dec-08-2022