He aha ka paclitaxel paʻa i ka albumin?

He aha ka paclitaxel paʻa i ka albumin?ʻO ka paclitaxel paʻa i ka Albumin (ʻike mau ʻia ʻo albumin paclitaxel, i hoʻopau ʻia ʻo Nab-P) he nanoformulation paclitaxel hou, i ʻike ʻia ma ke ao holoʻokoʻa ʻo ia ka hoʻokumu ʻana o ka paclitaxel.Hoʻohui ia i ka albumin kanaka endogenous me ka paclitaxel ma kahi ʻano non-covalent a ʻo nā nanoparticles hopena e lanakila loa i ka hemahema o ka paclitaxel hiki ʻole ke hoʻoheheʻe ʻia i ka wai, me ka ʻole o ka polyoxyethylene castor oil a i ʻole Tween 80 ma ke ʻano he co-solvent.ʻOiai ʻo albumin kahi huahana kūlohelohe endogenous, loaʻa iā ia nā pōmaikaʻi o ka palekana, non-toxic, non-immunogenic, biodegradable, a biocompatible.

No ke aha ʻo ka paclitaxel paʻa albumin ka mea kiʻekiʻe loa?

1. No co-solubilisationno pre-treatment

Ke hoʻohana nei i ka protein plasma o ke kumu maoli, hoʻopaʻa ia i nā molekala hydrophobic paclitaxel i kahi ʻano non-covalent me ka ʻole o ka co-solvent, e hoʻopau ana i ka hypersensitivity a me nā hopena toxicity i hoʻokumu ʻia e nā co-solvents, no laila e hoʻopau i ka pono no ka hoʻomaʻamaʻa hormone ma mua o ka hoʻohana ʻana a me ka pōkole o ka manawa infusion. i 30 mau minuke, e hoʻopōkole loa i ka noho ʻana o ka haukapila o nā mea maʻi oncology, a me ka hoʻopau ʻana i ka chemotherapy ma o ke keʻena lā.

2. ʻOi aku ka maikaʻi o ka pharmacokinetics

Ke hoʻohālikelike ʻia me ka paclitaxel maʻamau, ʻoi aku ka wikiwiki o ka paclitaxel albumin i ka hāʻawi ʻana i ka ʻiʻo i loko o ke kino, a me ka hoʻokuʻu lohi ʻana mai nā kiko, hiki ke hoʻonui nui ʻia ka nui o ke kino kanaka a hoʻomaikaʻi maikaʻi ʻia ka hopena therapeutic.

3. ʻO ka hoʻohui ʻana i ka maʻi maʻi kūloko

ʻO kekahi kumu e makaʻu ai ka poʻe maʻi i ka chemotherapy paclitaxel ʻo ia ka hoʻolaha ʻana o ka paclitaxel maʻamau i loko o nā ʻiʻo maʻamau a me nā ʻiʻo maʻamau ʻē aʻe, e hoʻoulu ai i nā hopena koʻikoʻi.Ma ka hoʻohālikelike ʻana, loaʻa i ka paclitaxel kahi "hoʻonui ʻia ʻana o ka tumo kūloko kūloko" a ʻoi aku ka kiʻekiʻe o kona neʻe ʻana i ka ʻiʻo maʻi maʻi ma mua o nā mea maʻamau.

Nānā: Ua lawe ʻia nā hopena a me nā noi i wehewehe ʻia ma kēia ʻatikala mai nā palapala i paʻi ʻia.

Yunnan Hande Bio-Tech Co., Ltd ua loea i ka hana oAPI paclitaxelʻoi aku ma mua o 20 mau makahiki, a ʻo ia kekahi o nā mea hana nui o ka honua i ka paclitaxel API me ka ʻae FDA, palapala CEP a me ka palapala GMP ma Kina.Hiki iā Hande ke hāʻawi i ka API paclitaxel kiʻekiʻe wale nō akālawelawe hoʻololi ʻenehana no ka paclitaxel albumin.No ka ʻike hou aku, e ʻoluʻolu e kelepona mai iā mākou ma 18187887160.